Project realization period: 01.03.2022-28.02.2026

Project is carried out in cooperation of the Medical University of Silesia in Katowice (Leader), National Institute of Oncology, Maria Skłodowskiej-Curie - National Research Institute - Branch in Gliwice and the Center of Polymer and Carbon Materials of the Polish Academy of Sciences.

The aim of the project is to develop the nanofibers with novel anticancer agents: betulin or its derivatives for a sustained drug release and with the proper mechanical properties (flexibility) using the innovative technique of electrospinning. The electrospun drug-loaded implants are intended to be implanted into a tumor resection cavity or directly into the tumor tissue (in case of the inoperable cancers), as postoperative chemotherapy of the cancers reducing the toxicity and side effects compared to the conventional systemic therapy. The project is mostly focused on breast cancer therapy and will involve in vitro analysis on cell lines and in vivo tests on mouse model of breast cancer.